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Phosphatidylserine vs Phosphatidylcholine Benefits

 Phosphatidylserine vs Phosphatidylcholine Benefits Compared

What are Phosphatidylserine and Phosphatidylcholine?

Phosphatidylserine and Phosphatidylcholine are two of the world’s most researched phospholipids (fatty acids) for their ability to support cognitive function, mental performance, memory, and neurology.

If you want to improve your health, you may wonder which phospholipid is best for you. Phosphatidylserine and phosphatidylcholine are both good options. However, they offer different benefits. Phosphatidylserine is good for cognitive function and memory. Phosphatidylcholine is good for liver health, cell membranes, and digestion.

Phosphatidylserine is a nutrient that helps keep cell membranes healthy. It is a powerful antioxidant that protects against damage from free radicals. The antioxidant and anti-inflammatory potential of phosphatidylserine is thought to be due to its ability to protect cell membranes from free radical damage, which may inhibit aging. Phosphatidylserine also has been shown to improve cognitive function and memory. Phosphatidylcholine is another nutrient that helps with cell membranes and aids liver function and fat metabolism.

So, which one should you take? The answer may depend on your specific needs. If you’re looking for cognitive benefits, phosphatidylserine may be the better choice. If you’re concerned about liver function or fat metabolism, phosphatidylcholine could be a better option. Discuss your specific needs with your doctor before deciding on a supplement.

What is Phosphatidylserine?


Phosphatidylserine is a naturally occurring substance in the body. It is found in the brain and around cell membranes to maintain healthy function.

How is phosphatidylserine made?

Phosphatidylserine is made by every cell in the body. The body needs choline to produce phosphatidylserine. Phosphatidylserine is made from choline by the enzyme serine racemase. The brain makes phosphatidylserine from the amino acid serine. Serine is the precursor of phosphatidylserine.

Where is phosphatidylserine found?

Phosphatidylserine is found in high concentrations in the brain, around cell membranes, and within nerve cells. It is also found in dietary sources like beef liver, red meats, spinach, fish, and soybeans.

There are many benefits of phosphatidylserine

Phosphatidylserine benefits and Brain Health

Phosphatidylserine may help support healthy brain function. It is a component of cell membranes, particularly in the hippocampus, a part of the brain that is important for memory. Phosphatidylserine is a fatty substance that is found in cell membranes. It helps cells communicate and plays a role in the production of acetylcholine, a neurotransmitter that helps communication between brain cells and supports memory which may help reduce the symptoms of age-related memory loss and cognitive deficits. Phosphatidylserine can help boost acetylcholine levels.

Phosphatidylserine has been studied in clinical trials and scientific studies for improving memory and learning and to help manage the symptoms of Alzheimer’s disease and cognitive impairment. It may be effective with other memory supplements like choline and Huperzine A.

Phosphatidylserine also helps regulate cortisol levels, a stress hormone often elevated in people with memory problems and depression.

How does phosphatidylserine regulate cortisol levels?

The adrenal gland secretes cortisol in response to stress. High levels of this hormone may impair memory and lead to depression. Phosphatidylserine can lower cortisol levels by several possible mechanisms. It may bind with cortisol in the bloodstream, preventing it from reaching the brain, where it would cause negative effects. It may also work by decreasing the amount of cortisol that is produced in the first place. Phosphatidylserine also appears to help lower cortisol levels by inhibiting the enzyme that makes cortisol in the first place.

Phosphatidylserine has been shown to lower cortisol levels in healthy people. In one study, the memory and alertness of a group of medical students were measured before and after taking phosphatidylserine. The students had higher cortisol levels on the day before a major exam. After taking phosphatidylserine, their cortisol levels decreased. They also reported better moods and improved memory.

Phosphatidylserine Benefits and the Immune System

Phosphatidylserine may help support healthy immune function. It helps regulate the activity of the immune system and is believed to help reduce inflammation.

 Phosphatidylserine may reduce inflammation by inhibiting the activity of the enzyme phospholipase A2. Phospholipase A2 is involved in the production of prostaglandins, which are chemicals that promote inflammatory reactions. Phosphatidylserine may help reduce the severity of allergies and asthma by decreasing inflammation.


Phosphatidylserine benefits and Muscle Health

Phosphatidylserine can help reduce muscle pain and soreness. It is also involved in the production of the neurotransmitters that help regulate muscle movement, which may be why it works to reduce muscle fatigue.

Phosphatidylserine Benefits and Liver Health

Phosphatidylserine protects the liver against alcohol-induced damage and improves its ability to metabolize fats. It can also help reduce the severity of liver disease by lowering inflammation in the liver.

Phosphatidylserine and Fatigue

Phosphatidylserine is a precursor to brain chemicals that are vital for energy production. It can help restore the balance of these chemicals, reducing fatigue and improving mental performance.

Phosphatidylserine and Sleep

Phosphatidylserine can promote sound sleep by reducing the stress hormone cortisol and increasing melatonin, a chemical that regulates the body’s sleep-wake cycle.

Phosphatidylserine and Depression

 Phosphatidylserine is a natural substance found in the brain that helps reduce the breakdown of endorphins, naturally produced chemicals that help relieve depression. Phosphatidylserine is also an antioxidant that blocks the oxidation of dopamine and serotonin, which has been found to help relieve depression. In a double-blind, placebo-controlled study of 80 adults with depression and anxiety, phosphatidylserine was found to improve depression.

Phosphatidylserine and Anxiety

Phosphatidylserine is a natural substance found in the brain that helps reduce the breakdown of endorphins, naturally produced chemicals that help relieve anxiety.

Phosphatidylserine and Glucose Levels

Phosphatidylserine has been shown to help reduce blood sugar in people with diabetes. It may help maintain healthy blood glucose levels by helping the body use insulin more efficiently.

Phosphatidylserine and Weight Loss

Phosphatidylserine has been shown to increase fat burning by activating the hormone receptors that control metabolism.

Phosphatidylserine and Heart Health 

Phosphatidylserine affects cardiovascular tissue, but it is unclear exactly how. Phosphatidylserine may help lower blood pressure by inhibiting ACE, a protein that regulates blood pressure. Some research suggests that phosphatidylserine may increase the pumping strength of the heart muscle and help regulate blood pressure, heart rhythm, and other cardiovascular functions.

The recommended dose of phosphatidylserine supplements is 100 to 400 mg daily.

What is Phosphatidylcholine?


Phosphatidylcholine is synthesized by the body when daily choline is ingested. The human body can produce choline without consuming it through food, not phosphatidylcholine. Phosphatidylcholine is a component of lecithin, which is used as a food additive. Lecithin can be found in egg yolks and soybeans, but it is also available in capsules or tablets that people might take as dietary supplements. Phosphatidylcholine is also found in meats, eggs, fish, and soybeans.

The body can’t make phosphatidylserine on its own, unlike phosphatidylserine. Phosphatidylcholine is a precursor molecule for the production of serine and other molecules.

How much is needed? The amount of phosphatidylcholine supplementation that people need each day is not known. There is not enough information to know if taking extra phosphatidylcholine will harm you.

What are phosphatidylcholine benefits?

Phosphatidylcholine is a phospholipid that can be converted into choline, another essential nutrient. It plays a role in many important brain functions, including memory and learning. In the brain, phosphatidylcholine is converted into acetylcholine, a neurotransmitter that plays an important role in memory, learning, and thinking.

Acetylcholine is the neurotransmitter that controls most of our voluntary movements. You should know that phosphatidylcholine is one of the few substances that can cross the blood-brain barrier and enter the brain tissue. This makes it one of the most potent cognitive enhancers available. Phosphatidylcholine is a potent antioxidant that protects brain cells from free radical damage. This helps delay the onset of Alzheimer’s, Parkinson’s, and other neurodegenerative disorders. Phosphatidylcholine is essential for developing myelin, a fatty substance that insulates neurons and speeds up information transfer. It may thus help prevent age-related cognitive decline. Phosphatidylcholine is essential for producing new brain cells and converting short-term and long-term memory. Phosphatidylcholine promotes cell membrane permeability, which helps control neurotransmitter release. It is thus essential for the formation of new synapses and intelligence. Phosphatidylcholine helps maintain a healthy inflammatory response by supporting the activity of macrophages, white blood cells that remove cellular debris. It also helps protect the liver and supports normal immune system function.

 Phosphatidylcholine Benefits and  Liver Health

The liver is the body’s largest organ and is responsible for removing harmful substances from the blood. When the liver becomes damaged, it can no longer function correctly. Phosphatidylcholine supplements may help reduce liver disease symptoms by slowing down or reversing liver damage. Phosphatidylcholine may also improve the liver’s ability to remove toxins from the blood, preventing them from accumulating in other body parts. Fatty liver disease is characterized by an accumulation of fat in the liver. Recent studies have shown that long-term use of phosphatidylcholine supplements can reduce fatty liver disease symptoms by reducing liver damage and improving the way the liver removes toxins from the blood.

 Phosphatidylcholine and Heart Health

Phosphatidylcholine supplements may help reduce the risk of heart disease by lowering LDL “bad” cholesterol levels and improving HDL “good” cholesterol levels. It also helps protect against heart attacks and cardiovascular disease by decreasing the number of fat deposits that can clog coronary arteries.

 Phosphatidylcholine Benefits Help  Memory 

Phosphatidylcholine can help improve memory and attention span in people with degenerative brain disorders. It may also help improve memory, concentration and focus in people with Down syndrome and other types of mental impairment.

Phosphatidylcholine Benefits and  Digestion
Phosphatidylcholine is used to produce bile acids, which help digest fats. It also inhibits the breakdown of fat-soluble vitamins A, D, E, and K. Phosphatidylcholine is used to produce bile acids, which help the digestion of fats. It also inhibits the breakdown of fat-soluble vitamins A, D, E, and K. Ulcerative colitis, a chronic inflammatory disease of the colon, is characterized by diarrhea, abdominal pain and cramping, and bleeding. Phosphatidylcholine helps reduce the symptoms of ulcerative colitis. It may help improve symptoms of irritable bowel syndrome (IBS). Phosphatidylcholine may also help reduce the symptoms of gallbladder disease.

Phosphatidylcholine  Benefits and and Fat Metabolism
Phosphatidylcholine is used in the breakdown of fats.

Phosphatidylcholine Benefits  and Energy Production
The breakdown of phosphatidylcholine results in energy production through aerobic metabolism.

Phosphatidylcholine Benefits and Muscle Metabolism Phosphatidylcholine produces acetylcholine, which helps with muscle contraction and relaxation.

In conclusion, phosphatidylserine and phosphatidylcholine benefits are many, but depending on the person’s needs, one may be better. Phosphatidylserine is good for cognitive function and memory, while phosphatidylcholine is good for cardiovascular health and liver function. Speak with a doctor to see which phospholipid would be best for you.

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About Author

Picture of  Ava Bell-Taylor, M.D

Ava Bell-Taylor, M.D

Ava Bell-Taylor, M.D., originally from Atlanta, Georgia, received her Bachelor of Science degree from Spelman College. She later received her medical degree from Morehouse School of Medicine. She completed her Family Practice training at Floyd Medical Center in Rome, Georgia and her psychiatry residency at Emory University School of Medicine. Dr. Bell-Taylor has extensive post-graduate medical training in Functional, Integrative, and Anti-Aging Medicine. She is certified in Functional Medicine. Ava Bell-Taylor, M.D. is a holistic doctor with a focus on functional and integrative medicine. Combining functional medicine with her knowledge of conventional medicine has enabled Dr. Bell-Taylor to help many patients suffering from depression, anxiety, insomnia, attention-deficient, dementia, and eating disorders. Dr. Bell-Taylor specializes in functional medicine with a special emphasis on how hormone disorders, environmental factors, lifestyle choices, and nutritional deficiencies contribute to brain dysfunction, like depression, attention deficiency, anxiety, insomnia, dementia, and other chronic medical illnesses. Dr. Ava Bell- Taylor is the co-author with her husband, Eldred B, Taylor, M.D, of two must-read books, Are Your Hormone Making You Sick? and The Stress Connection: How Adrenal Gland Dysfunction Effects Your Health.

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