Vitamin C (Ascorbic Acid)

The adrenal gland contains the highest concentration of Vitamin C of any organ in the body — 100x higher than plasma levels. Vitamin C is an essential cofactor for the enzyme dopamine beta-hydroxylase, which converts dopamine to norepinephrine, and for the hydroxylation reactions required in cortisol synthesis. Under stress, the adrenal gland depletes its Vitamin C stores rapidly.

This is not a general immune-support dose — this is an adrenal-targeted therapeutic dose. At 500mg, it replenishes the adrenal gland's specific Vitamin C requirement for cortisol synthesis. Without adequate Vitamin C, the adrenal gland cannot produce cortisol efficiently regardless of how much glandular extract or adaptogens are provided.

Multiple studies confirm that Vitamin C supplementation reduces cortisol response to acute stress, supports adrenal recovery after exercise-induced stress, and reduces the duration of adrenal fatigue symptoms. The adrenal gland's unique Vitamin C concentration is well-established in endocrinology literature.

500mg is the therapeutic adrenal-support dose. Best taken with the adrenal glandular extract in the morning. Vitamin C is water-soluble — split dosing (AM/PM) improves retention.