Panax Ginseng

Ginsenosides (the active compounds) modulate the HPA axis, support nitric oxide production for vascular health, enhance immune function via NK cell activation, and support cognitive function through acetylcholine pathway modulation. Panax ginseng is the most studied ginseng species for cognitive performance and energy.

Used specifically for the cognitive and energy dimensions of adrenal fatigue — the mental fog, poor concentration, and motivational deficits. Complements adrenal glandular extract by addressing the brain-side effects of cortisol dysregulation.

Extensive clinical research including RCTs showing improved cognitive performance, reduced mental fatigue, enhanced immune function, and improved quality of life. A 2010 Cochrane-style review confirmed cognitive benefits in healthy adults.

200–400mg standardized extract daily. Best taken in the morning. Avoid in patients with hypertension or those taking blood thinners without physician oversight.